Eltrom (Eltrombopag) Tablets 50mg are used to treat low platelet count (thrombocytopenia) in patients with immune thrombocytopenic purpura (ITP) and chronic liver disease. Eltrom 50mg tablets work by stimulating platelet production in the bone marrow, helping reduce the risk of bleeding.
Doctors prescribe Eltrombopag tablets 50mg to patients who do not respond adequately to standard treatments. Eltrom Tablets are widely used in hematology and require regular monitoring under medical supervision.
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Uses
Eltrombopag is used to treat thrombocytopenia (low platelets in the blood) in patients with a blood disorder called chronic immune thrombocytopenia (ITP). This medicine is used after a splenectomy (surgery to remove the spleen) and other medicines (eg, steroids or immunoglobulin) have not worked well enough. Eltrombopag is also used to treat thrombocytopenia in patients with chronic hepatitis C, along with interferon treatment. Platelets help clot the blood, so a person with thrombocytopenia may have bleeding problems. Eltrombopag works by stimulating the bone marrow to produce more platelets.
Eltrombopag is used together with standard immunosuppressive treatment for the first-line treatment of severe aplastic anemia (SAA) in adults and children 2 years of age and older. It is also used to treat SAA in patients who have received other medicines that did not work well.
Dosage
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For first-line treatment of severe aplastic anemia:
For oral dosage forms (Promacta® suspension or tablets):
Adults and children 12 years of age and older—At first, 150 milligrams (mg) once a day for 6 months. Some patients may start at a lower dose. Your doctor may adjust your dose as needed.
Children 6 to 11 years of age—At first, 75 mg once a day for 6 months. Some patients may start at a lower dose. Your doctor may adjust your dose as needed.
Children 2 to 5 years of age—Dose is based on weight and must be determined by your doctor. At first, 2.5 milligram per kilogram (mg/kg) of body weight once a day for 6 months. Some patients may start at a lower dose. Your doctor may adjust your dose as needed.
Children younger than 2 years of age—Use and dose must be determined by your doctor.
For refractory severe aplastic anemia:
For oral dosage forms (Promacta® suspension or tablets):
Adults—At first, 50 milligrams (mg) once a day. Some patients may start at a lower dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day.
Children—Use and dose must be determined by your doctor.
Warnings and Precautions
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Alvaiz™: Appropriate studies have not been performed on the relationship of age to the effects of eltrombopag for the treatment of ITP in children younger than 6 years of age and for the treatment of chronic hepatitis C and severe aplastic anemia in children. Safety and efficacy have not been established.
Promacta®: Safety and efficacy have not been established to treat ITP in children younger than 1 year of age, or in children with thrombocytopenia associated with chronic hepatitis C or severe aplastic anemia.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of eltrombopag in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require caution and an adjustment in the dose for patients receiving eltrombopag.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Eltrombopag may cause or increase the risk for serious liver problems. Check with your doctor right away if you or your child start having nausea or vomiting, dark urine, light-colored stools, right upper stomach pain, unusual tiredness, or yellow eyes or skin while using this medicine.
This medicine may increased risk for blood or bone marrow problems (eg, myelodysplastic syndrome, acute myeloid leukemia). Check with your doctor right away if you have chest pain, chills, cough or hoarseness, fever, lower back or side pain, painful or difficult urination, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.
Blood clotting problems may occur while you or your child are using this medicine. Check with your doctor right away if you or your child have pain, swelling, or tenderness in your leg, or pain in your chest.
Do not stop using this medicine without checking first with your doctor. Your doctor will check your platelet levels and progress before you stop using the medicine.
This medicine may cause cataracts or make them worse. Check with your doctor right away if you or your child have blurred vision, difficulty in reading, or any other change in vision while using this medicine. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).
Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect certain medical test results (eg, bilirubin, creatinine).
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
