Trexat (Methotrexate) Tablets 10mg is used to treat cancer, rheumatoid arthritis, psoriasis, and autoimmune diseases. It works by slowing abnormal cell growth and suppressing immune system activity.
Methotrexate is commonly prescribed by specialists for long-term disease management under medical supervision.
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Uses
Methotrexate tablet is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood (eg, acute lymphoblastic leukemia or ALL), bone, lymph node (eg, mycosis fungoides, relapsed or refractory non-Hodgkin lymphoma), or uterus cancer. It is also used to treat rheumatoid arthritis, severe psoriasis (a skin disease), lupus, multiple sclerosis, and polyarticular juvenile idiopathic arthritis.
Methotrexate oral solution is used together with other medicines to treat acute lymphoblastic leukemia (ALL) or non-Hodgkin lymphoma that has come back (relapsed) or did not respond to previous treatment (refractory). It is also used alone or together with other medicines to treat mycosis fungoides. This medicine is also used to treat rheumatoid arthritis, severe psoriasis (a skin disease), and polyarticular juvenile idiopathic arthritis.
Dosage
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets):
For acute lymphoblastic leukemia (ALL):
Adults and children—Dose is based on body size and must be determined by your doctor. At first, 20 milligrams (mg) per meter squared (m(2)) of body size once a week. Your doctor may adjust your dose as needed and tolerated.
For mycosis fungoides:
Adults—
Used alone: 25 to 75 milligrams (mg) once a week.
Used with other medicines: Dose is based on body size and must be determined by your doctor. The dose is usually 10 mg per meter squared (m(2)) of body size 2 times a week.
Children—Use and dose must be determined by your doctor.
For non-Hodgkin lymphoma:
Adults—2.5 milligrams (mg) 2 to 4 times a week. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 10 mg per week.
Children—Use and dose must be determined by your doctor.
For polyarticular juvenile arthritis (pJIA):
Children—Dose is based on body size and must be determined by your doctor. At first, 10 milligrams (mg) per meter squared (m2) once a week. Your doctor may adjust your dose as needed and tolerated.
For psoriasis:
Adults—At first, 10 to 25 milligrams (mg) once a week. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 30 mg per week.
Children—Use and dose must be determined by your doctor.
For rheumatoid arthritis:
Adults—At first, 7.5 milligrams (mg) once a week. Your doctor may adjust your dose as needed and tolerated.
Children—Use and dose must be determined by your doctor.
Warnings and Precautions
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methotrexate for the treatment of acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis in children. However, safety and efficacy have not been established in children with other conditions.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methotrexate in the elderly.
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. Blood and urine tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. The medicine may also cause birth defects if it is used by the father when his sexual partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use an effective form of birth control during treatment and for at least 3 or 6 months after the last dose. Male patients who have female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose. Tell your doctor right away if pregnancy occurs while you are using this medicine.
This medicine may cause serious allergic reactions, including anaphylaxis, which may be life-threatening and require immediate medical attention. Check with your doctor right away if you have a rash, itching, dizziness, fainting, fast heartbeat, trouble breathing or swallowing, or chest tightness while you are using this medicine.
Talk with your doctor before using this medicine if you plan to have children. Some men and women who use this medicine have become infertile (unable to have children).
